Particle Insight
Dynamic Size and Shape Monitoring of Crystal Growth
Particle morphology of crystal growth provides important information regarding the physical shape properties of your API sample. By knowing true size and shape, with visual confirmation, the end user can determine when the crystallization process ends. Software assists with enabling downstream processes such as valve actuation and starting milling operations for Continuous Manufacturing processes for true on-line control.
The Particle Insight Process Monitoring System is a class-leading dynamic image analyzer that is ideal for applications where particle shape, not just the particle size, may be critical information for predicting raw material quality and to maintain a high level of process control. The Process Monitoring System is an on-line adaptation of a proven system that has been serving the Pharmaceutical market for well over 10 years.
Competitive systems offer qualitative information or cord length measurements. Particle Insight offers proper dispersion and high-quality imaging to give more than 31 shape measurements on each particle as well as concentration.
| A | B | C |
|---|---|---|
| High speed, high resolution, Real-time number-based results. | Security and regulatory compliance, 21CFR11 and Data Integrity | Robust Instrument Qualification Program for regulatory compliance needs. |
| More than 30 size and shape measures to classify every measured particle. | Flexible, fluidic design allows easy adaptation to crystallization processes or any other sample vessel with organic solvent compatibility. | Particle classification allows for automatic analysis of subcomponents of mixed sample. |
| Multi-run overlaying of shape data to analyze process changes over time. | Automatic real-time data backup. | Particle Concentration Capability and rare event detection |
| Particle thumbnails for Visual confirmation. | Numerous size range model options. | 3-Dimensional analysis with random orientation. |
| Sieve correlation capability | Upgradeable optics to extend particle range | Portable design allows for fixed use as well as troubleshooting capabilities. |