At INTERPHEX, we had the opportunity to demonstrate how dynamic image analysis can be applied to particle inspection in pharmaceutical and biotech environments.
This short demo highlights several important aspects of particle analysis that go beyond traditional counting methods.
Seeing Particles in Motion
One of the key advantages of dynamic imaging is the ability to observe particles. Statistics, counts, and concentrations are all reported with thumbnail imgages that serve as objective evidence of what is in your sample offering a good insight to identifying the source of contamination.
Sample Suspension and Fluidics Matter
Proper suspension is critical for accurate particle analysis. In this demo, we discuss how different suspension approaches can impact results, including:
- Preventing particles of interest from settling
- Reducing the impact of buoyant artifacts such as silicone oil droplets
- Using fast fluidics to maintain a representative sample
These factors are often overlooked but can significantly influence data quality.
Classification by Shape and Population Analysis
Dynamic image analysis enables classification of particles based on morphology, not just size.
In the demo, we show how particles can be grouped into different populations based on shape, with results reported as:
- Total counts per population
- Percentage of total particle population
This provides deeper insight into what is actually present in the sample, which is critical for investigation and root cause analysis.
Reporting USP <788> Results
In addition to advanced characterization, the system also reports USP <788> particle count results, allowing users to maintain alignment with established compendial requirements while gaining additional insight.
Why This Matters
Traditional particle counting methods provide limited information — primarily counts and size.
Dynamic image analysis adds a critical layer of understanding by combining:
- Particle size
- Particle shape
- Visual confirmation
This enables better decision-making in applications involving:
- Quality control
- Contamination monitoring
- Investigations
👉 Learn more about the Raptor 1788 system here:
Raptor 1788.3 Compliance – Particle Shape Particle Size